One‐Pot Catalytic Glycosidation/Fmoc Removal – An Iterable Sequence for Straightforward Assembly of Oligosaccharides Related to HIV gp120

Abstract

Abstract The removal of a transient Fmoc protecting group can be simply performed by the addition of excess Et 3 N just after the accomplishment of a Bi(OTf) 3 ‐promoted glycosidation reaction. The obtained oligosaccharide can be directly employed as a glycosyl acceptor for further elongation of the saccharide. The preparation of biologically important, linear and branched mannans incorporated into HIV gp120 demonstrates that the iteration of this one‐pot sequence leads to a very straightforward oligosaccharide assembly.