Na+???Ca2+ exchange modulates Ca2+ handling of human platelets by altering intracellular Ca2+ store size

Abstract

These results suggest that Na(+)-Ca2+ exchange is important in extruding Ca2+ from the cytosol in human platelets, and inhibition of this exchange leads to the accumulation of intracellular Ca2+ store, which may be responsible for the enhanced responsiveness of cytosolic free Ca2+ to agonists.