Peroxisome Proliferator-Activated Receptor-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>(PPAR-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>γ</mml:mi></mml:math>) Agonists Attenuate the Profibrotic Response Induced by TGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>β</mml:mi></mml:math>1 in Renal Interstitial Fibroblasts

Abstract

PPAR-gamma agonists could inhibit TGF-beta1-induced renal fibroblast activation, CTGF expression and ECM synthesis through abrogating the TGF-beta1/Smads signaling pathway.