C−C Bond-Forming Click Synthesis of Rotaxanes Exploiting Nitrile <i>N</i>-Oxide

Abstract

A click end-capping reaction exploiting nitrile N-oxide to rotaxane was described with emphasis of productivity of the protocol via stable C-C bond formation. Establishment of a pH-driven molecular shuttling system was also demonstrated by practical neutralization of the sec-ammonium group of the rotaxane axle with potassium hydroxide.