Dual Organocatalytic Ion‐Pair Assemblies: A Highly Efficient Approach for the Enantioselective Oxa‐Michael–Mannich Reaction of Salicylic Aldehydes with Cyclohexenones

Abstract

Better in pairs: A highly efficient asymmetric reaction of salicylic aldehydes with cyclohexenones by means of a domino oxa-Michael–Mannich pathway has been achieved by using novel dual organocatalytic ion-pair assemblies from pyrrolidines and readily available primary amino acids (see scheme).