Pharmacology · 2008 · 15 citations · 0 references
Life SciencesNeurosciencePhysiologyBehavioral NeuroscienceNeuroendocrinologyNeuropharmacologyDopaminergic SignalingSleep BehaviorSleep PhysiologySleep PsychophysiologySleep-wake NeurobiologySleep-wake RegulationCholinergic ToneDopaminergic Arousal RegulationRem Sleep MechanismsSerotonergic Sleep-wake RegulationSleepSleep NeurobiologySleep NeurochemistrySleep-related Hormonal Responses
Central administration of ACTH in rats induces yawning and stretching. In order to study the effects of REM sleep deprivation on ACTH-induced yawning, the peptide was injected immediately after the REM sleep deprivation period or 24 h later. REM sleep deprivation impaired ACTH-induced yawning, but after a 24-hour recovery period, rats displayed a number of yawns similar to those in control animals. Implications for an involvement of dopaminergic and mainly cholinergic systems are discussed.