<i>seco</i>-Abietane Diterpenoids, a Phenylethanoid Derivative, and Antitubercular Constituents from <i>Callicarpa pilosissima</i>

Abstract

Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9alpha-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated from the leaves and twigs of Callicarpa pilosissima, together with 14 known compounds (7-20). The structures of these new compounds were determined through analyses of physical data. 12-Deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid B (5), and alpha-tocopherol trimer B (15) exhibit antitubercular activities (MICs <or= 63.6 microM) against Mycobacterium tuberculosis H(37)Rv in vitro.