Neurotrophic Agents in Fibrin Glue Mediate Adult Dorsal Root Regeneration into Spinal Cord

Abstract

Our results indicate that neurotrophin-3, brain-derived NTF, and ciliary NTF enhance dorsal root regeneration into spinal cord and that fibrin glue is an effective medium for intraspinal delivery of NTF. This method of delivering NTF may therefore provide a strategy for restoring injured spinal reflex arcs.