F15063, a potential antipsychotic with D<sub>2</sub>/D<sub>3</sub>antagonist, 5‐HT<sub>1A</sub>agonist and D<sub>4</sub>partial agonist properties: (I)<i>in vitro</i>receptor affinity and efficacy profile - Concepedia

Concepedia

Publication | Open Access

F15063, a potential antipsychotic with D<sub>2</sub>/D<sub>3</sub>antagonist, 5‐HT<sub>1A</sub>agonist and D<sub>4</sub>partial agonist properties: (I)<i>in vitro</i>receptor affinity and efficacy profile

DOI Full Paper Access

38

Citations

67

References

2007

Year

Adrian Newman‐Tancredi, M‐B Assié, J‐C Martel, Cristina Cosi, L. Bruins Slot, Christiane Palmier, Isabelle Rauly‐Lestienne, F. C. Colpaert, Bernard Vacher, Didier Cussac

British Journal of Pharmacology

Abstract

F15063 antagonised dopamine D(2)/D(3) receptors, a property underlying its antipsychotic-like activity, whereas activation of 5-HT(1A) and D(4) receptors mediated its actions in models of negative symptoms and cognitive deficits of schizophrenia (see companion papers).

References

	Year	Citations

Page 1