CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

A simple method for displaying the hydropathic character of a protein

Jack Kyte, Russell F. Doolittle · Journal of Molecular Biology · 1982 · 23.1K citations

Life Sciences, Biochemistry, Molecular Biology +12

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

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Life Sciences, Bioinformatics, Molecular Biology +17

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature · 1996 · 3.1K citations

Life Sciences, Developmental Biology, Genetics +14

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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Life Sciences, Neurobiology, Neuroscience +13

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

Richard K. Wilson, R. Ainscough, Kimberly Anderson et al. · Nature · 1994 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +10