Lack of emergence of significant resistance in vitro and in vivo to the new azalide antibiotic azithromycin

The pharmacokinetics of azithromycin in human serum and tissues

George Foulds, Richard M. Shepard, Raymond B. Johnson · Journal of Antimicrobial Chemotherapy · 1990 · 759 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms

James A. Retsema, Agnès Girard, W Schelkly et al. · Antimicrobial Agents and Chemotherapy · 1987 · 461 citations

Medicine, Infectious Diseases, Medicinal Chemistry +11

Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution

Agnès Girard, D Girard, A. R. English et al. · Antimicrobial Agents and Chemotherapy · 1987 · 323 citations

Medicine, Pharmacokinetics, Pharmacology +14

Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a-homoerythromycin A derivatives; A new class of macrolide antibiotics, the azalides.

G. Michael Bright, A. Nagel, Jon Bordner et al. · The Journal of Antibiotics · 1988 · 238 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus

Ching‐Juh Lai, James E. Dahlberg, Bernard Weisblum · Biochemistry · 1973 · 96 citations

Life Sciences, Microbiology, Molecular Biology +13