Combination Treatment With Nefazodone and Cognitive-Behavioral Therapy for Relapse Prevention in Alcohol-Dependent Men

Abstract

The results from this carefully designed clinical trial suggest that the 4 treatment combinations do not differ substantially in their efficacy for relapse prevention in nondepressed, severely alcohol-dependent patients. Nefazodone might even increase the risk of consuming a larger amount of ethanol per relapse in a subset of patients. CBT as performed in this study was associated with little additional benefit compared with structured GC.