Time Correlation Between the Effects of Reserpine on Behaviour and Storage Mechanism for Arylalkylamines

Abstract

Abstract The time course of the effect of reserpine on the ability of the adrenal medullary granules to take up arylalkylamines in vivo has been studied. It was observed that there was a closer correlation in time between the effects of the drug on the uptake of the amines by the granules and behaviour than between the latter and the tissue amine content. The finding is in accordance with a hypothesis that new‐formed arvlalkylamines arr at first transferred to sites in the granules where they are easily available for physiological release.