The Journal of Antibiotics · 1995 · 16 citations · 2 references
Life SciencesMedicinal ChemistryMolecular BiologyDrug DiscoverySignal TransductionStructural BiologyEnzyme InhibitionLigand BindingProtein Kinase CascadesMolecular Structure DeterminationMyosin InhibitorsProtein Structure Determination
MS-444 is a novel myosin light chain kinase inhibitor, isolated from the culture broth of Micromonospora sp. KY7123. The structure of MS-444 was determined to be 5,8-dihydroxy-3-methyl-(9H)-naphtho[2,3-c]furan-4-one by means of spectral analysis.
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