Human intrabony defect regeneration with rh<scp>FGF</scp>‐2 and hyaluronic acid – a randomized controlled clinical trial

TLDR

The study evaluated whether a recombinant human FGF‑2/hyaluronic acid hydrogel applied to periodontal intrabony defects improves regeneration of the periodontal attachment apparatus. In a randomized design, each patient’s two contralateral intrabony defects were assigned either standard open debridement with papilla‑preservation flaps or the same procedure plus topical rhFGF‑2/HA, with probing depth, recession, attachment level, and bone level measured at baseline and after one year. The rhFGF‑2/HA treatment produced greater probing depth reduction, attachment level gain, and residual probing depth, with 100 % of test sites achieving residual PD < 5 mm and 60 % achieving >4 mm PAL gain versus 0 % and 20 % in controls, indicating significant clinical improvement after one year.

Abstract

The goal of this study was to evaluate if a biological hydrogel of recombinant human Fibroblast Growth Factor type 2 (rhFGF-2) in a hyaluronic acid (HA) carrier applied in periodontal intrabony defects would enhance the clinical parameters of regeneration of the periodontal attachment apparatusThirty adult patients were evaluated. Two intrabony defects present in contra-lateral quadrants in each patient were randomly allocated for each of the treatment methods employed. Control group (n = 30) were treated by open debridement with the papilla preservation flaps, while the test group (n = 30) also received a topical application of rhFGF-2/HA in the intrabony defect. The parameters evaluated, at baseline and after one year, were, were probing depth (PD), gingival recession (REC), probing attachment level (PAL) and probing bone level (PBL). The primary outcome measures was PAL gainTest sites exhibited significantly more PD reduction (5.5 versus 2.9 mm), PAL gains (4.8 versus 2.2 mm) and shallower residual PD (4.2 versus 6.6 mm) than controls. Moreover, residual PD smaller than 5 mm (100 versus 0%) and PAL gain > 4 mm (60 versus 20%) was significantly more frequent in the test groupApplication of rhFGF-2/HA significantly improved clinical parameters of periodontal wound healing one year after treatment.