BAL alleviation of arsenate‐induced teratogenesis in mice

Abstract

Abstract Treatment of pregnant mice ip with 40 mg/kg aqueous sodium arsenate on gestation day 9 resulted in a significant increase in fetal mortality and malformation, and in fetal weight reduction. Treatment sc with 50 mg/kg BAL 4 h before, concurrently with, or 4 h after arsenate reduced the frequency or severity of malformation compared with the effects of arsenate alone.