Genetic Analysis of Resistance to Cadmium-Induced Testicular Damage in Mice

Abstract

SummaryResistance to cadmium-induced testicular necrosis is determined by a single autosomal recessive gene (cdm) in inbred mice. Forty-five inbred strains, six F1 hybrids, 14 congenic resistant strains, and 23 recombinant strains were tested for cadmium-induced testicular damage. The cdm gene is not closely linked with several gene loci.The authors thank Drs. George Snell and Marianna Cherry for providing the congenic strains. This study was conducted under Research Contract PH43-67-744 within the Special Virus-Cancer Program of the National Cancer Institute, NIH. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.