Journal of Pharmacobio-Dynamics · 1978 · 13 citations · 0 references
MedicineNeurosciencePharmacologyNeuropharmacologyPharmacodynamicsStress PhysiologyAutonomic Nervous SystemAutonomic Nervous System PharmacologyAutonomic Nervous System ResponsesAutonomic PharmacologyCholinergic PharmacologyRodent PhysiologyAdrenergic SignalingAnticholinergic DrugsAutonomic Cholinergic PharmacologyAutonomic Cholinergic TransmissionAutonomic Nervous System EffectsCold Stress ResponsesRodent Autonomic Nervous SystemStress
Responses to ACh, pilocarpine, BaCl2 and KCl in isolated duodenum from SART stressed mice (specific stress caused by alternating rhythm in temperature) were investigated using the Magnus's method, and the results were compared with those seen in non-stressed mice. We found that the ACh response was significantly decreased, while the BaCl2 response was not decreased in SART stressed mice duodenum, as compared with the non-stressed controls. And it is recognized that pretreatment with adrenergic and anticholinergic drugs inhibited the decrease of ACh response. These results suggest that SART stressed mice may be unbalanced in the autonomic nervous system.