A Simple and efficient Synthesis of 3,4-Dihydropyrimidin-2-Ones catalysed by Amidosulfonic Acid

Abstract

A general and practical route for the synthesis of dihydropyrimidines by the one-pot cyclocondensation of aldehydes, β-ketoesters and urea is described using NH 2 SO 3 H as catalyst. Yields and selectivities are significantly better than under classical Biginelli reaction conditions.