Pharmacokinetics of acebutolol after intravenous bolus administration.

Abstract

found that some 30% and 56% of the dose of radioactivity was excreted in urine during 24 and 144 h respectively after dosing. These workers estimated that about 80% of the urinary radioactivity was unchanged metolazone and thus some 24% and 45% of the administered drug was excreted unchanged in these time periods. The recovery of metolazone in urine during 24 h in the present study is thus similar to that reported by Tilstone et al. (1974).