Release of Peptide Promoted by the GGQ Motif of Class 1 Release Factors Regulates the GTPase Activity of RF3

A ratchet-like inter-subunit reorganization of the ribosome during translocation

Joachim Frank, Rajendra K. Agrawal · Nature · 2000 · 803 citations

Protein Folding, Molecular Biology, Protein Transport +4

The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis

Haiwei Song, Pierre Mugnier, Amit Kumar Das et al. · Cell · 2000 · 464 citations · Full text

Crystal Structure, Protein Function, Biochemistry +8

Release factors differing in specificity for terminator codons.

Edward M. Scolnick, Richard K. Tompkins, T. Caskey et al. · Proceedings of the National Academy of Sciences · 1968 · 379 citations · Full text

Bioorganic Chemistry, Genetics, Terminator Trinucleotide +18

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis

Ludmila Frolova, Ruslan Tsivkovskii, G. F. Sivolobova et al. · RNA · 1999 · 359 citations · Full text

Genetics, Molecular Biology, Protein Synthesis +16

Large-Scale Movement of Elongation Factor G and Extensive Conformational Change of the Ribosome during Translocation

Holger Stark, Marina V. Rodnina, Hans‐Joachim Wieden et al. · Cell · 2000 · 296 citations · Full text

Extensive Conformational Change, Protein Biosynthesis, Macromolecular Machine +7