In Vitro, Lidocaine-Induced Axonal Injury Is Prevented by Peripheral Inhibition of the p38 Mitogen-Activated Protein Kinase, but Not by Inhibiting Caspase Activity

Abstract

Whereas inhibition of either p38 mitogen-activated protein kinase or caspase activity promote neuronal survival after LA treatment of dissociated neuronal cultures, axonal degeneration induced by lidocain (40 mM) is prevented by p38 MAP kinase but not by caspase inhibition. We conclude that processes leading to LA-induced neurotoxicity in dissociated neuronal culture may be different from those observed after purely axonal application.