Concepedia

Effects of TGF-β2 on Cadherins and β-Catenin in Human Trabecular Meshwork Cells

Thomas Wecker, Juliane Börner, Franz Grehn, Günther Schlunck

Investigative Ophthalmology & Visual Science · 2013 · 33 citations · 22 references

DOI

Abstract

The cytokine TGF-β2 enhances cadherin-mediated cell-cell adhesion and β-catenin expression in HTM cells. Increased cell-cell adhesion may contribute to biomechanical alterations in glaucomatous trabecular meshwork (TM), and changes in β-catenin levels and its possible sequestration to cell adhesion sites may affect Wnt signaling. Thus, the crosstalk of TGF-β2 and Wnt signaling in TM may deserve further investigation.

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