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MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug DesignPeptide TherapeuticMdl 74147Human ReninDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryInhibitory ActivityDrug DiscoveryNovel Selective