Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) Gene are Associated with Severe Chronic Rhinosinusitis Unresponsive to Medical Therapy

Abstract

Polymorphisms of the SERPINA1 gene are associated with clinically severe CRS. These results, from a small subset of individuals with CRS, suggest that defects in AAT may be implicated in a subset of individuals unresponsive to conventional therapy and suggests that alternate therapies may be required for their management.