The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel

Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis

Erwin Oechslin, Christine H. Attenhofer Jost, Philipp A. Kaufmann et al. · Journal of the American College of Cardiology · 2000 · 1.2K citations

Medicine, Cardiology, Internal Medicine +7

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

Dario DiFrancesco, Paolo Tortora · Nature · 1991 · 848 citations

Life Sciences, Cell Biology, Physiology +16

Mutations in Cypher/ZASPin patients with dilated cardiomyopathy and left ventricular non-compaction

Matteo Vatta, Bhagyalaxmi Mohapatra, Shinawe Jimenez et al. · Journal of the American College of Cardiology · 2003 · 515 citations

Medicine, Cardiology, Genetics +12

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

Juliane Stieber, Stefan Herrmann, Susanne Feil et al. · Proceedings of the National Academy of Sciences · 2003 · 460 citations · Full text

Medicine, Cardiology, Developmental Biology +17

Familial Sinus Bradycardia Associated with a Mutation in the Cardiac Pacemaker Channel

Raffaella Milanesi, Mirko Baruscotti, Tomaso Gnecchi‐Ruscone et al. · New England Journal of Medicine · 2006 · 397 citations · Full text

Medicine, Cardiology, Genetics +13