Présence d'une Protéine D'origine Tissulaire, L'α₂H‐Globuline, Dans le Sérum de Sujets Atteints d'Affections Malignes

Abstract

Presence of a tissue protein, α 2 H globulin, in the serum of patients with neoplastic diseases The presence of an α 2 globulin of probable hepatic origin has been demonstrated by immunodiffusion and radioimmunodiffusion techniques in sera of patients with neoöplastic diseases. — 199 out of 395 (50%) of the sera of cancer patients were positive for α 2 H . — 71 out of 355 (20%) of pathological but non cancerous sera were positive for α 2 H . — None of the 45 normal control sera showed the presence of the α 2 H protein . The α 2 H protein is found more frequently in cancerous than in non cancerous sera. However, at present, a diagnostic test cannot be derived from its absence or presence. The discovery of a malignancy in a certain number of sera originally classified as non cancerous incites to pursue our investigations. The elevated percentage of positive pathological sera is suggestive of a reactivity factor. Different factors liable to interfere with the results are discussed. The presence of α 2 H could be a symptom of a metabolic hepatic reaction similar to that giving rise to the α 2 AP globulin in the rat.