Metabolism of Ethanol and Alcoholism: Racial and Acquired Factors

Abstract

Editorial Notes1 February 1972Metabolism of Ethanol and Alcoholism: Racial and Acquired FactorsCHARLES S. LIEBER, M.D., F.A.C.P.CHARLES S. LIEBER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-326 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of alcoholism is steadily increasing. Although no group is immune, various segments of our society are differently affected. It is generally recognized that American Jews are relatively spared, whereas American Indians seem to be more prone to alcoholism. These differences are commonly attributed to cultural factors, although genetic influences have not been ruled out. A hereditary link between alcoholism, cirrhosis, and color blindness has been implicated by some investigators (1) but denied by others (2). Other studies have focused on alcohol preference in inbred animals. Despite some discrepant findings, "alcohol preferring" strains do not show a predisposition for...References1. UGARTECRUZ-COKERIVERA GRL: Relationship of color blindness to alcoholic liver damage. Pharmacology 4:297-308, 1970 CrossrefMedlineGoogle Scholar2. RIFFENBURGSHEA RJ: Lack of association between color blindness and alcoholism. Eye Ear Nose Throat Mon 49:240-242, 1970 MedlineGoogle Scholar3. VON WARTBURGPAPENBERG JJ: Alcohol dehydrogenase in ethanol metabolism. Psychosom Med 28:405-413, 1966 CrossrefGoogle Scholar4. EDWARDSPRICE-EVANS JD: Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase. Clin Pharmacol Ther 8:824-829, 1967 CrossrefMedlineGoogle Scholar5. FENNAMIXSCHAEFER DLO: Ethanol metabolism in various racial groups. Can Med Assoc J 105:472-475, 1971 MedlineGoogle Scholar6. MISRALEFEVREISHII PAH: Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med 51:346-351, 1971 CrossrefMedlineGoogle Scholar7. LIEBERDECARLI CL: Hepatic microsomal ethanol oxidizing system: in vitro characteristics and adaptive properties in vivo. J Biol Chem 245:2505-2512, 1970 CrossrefMedlineGoogle Scholar8. LIEBERDECARLI CL: Effect of drug administration on the activity of the hepatic microsomal ethanol oxidizing system. Life Sci [II] 9:267-276, 1970 CrossrefGoogle Scholar9. LIEBERDECARLI CL: Paradoxical effects of barbiturates on ethanol metabolism (abstract). Gastroenterology 60:177, 1971 Google Scholar10. RUBINGANGMISRA EHP: Inhibition of drug metabolism by acute intoxication: a hepatic microsomal mechanism. Am J Med 49:801-806, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mt. Sinai School of Medicine of the City University of New York Veterans Administration Hospital Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCreatine supplementation exacerbates ethanol-induced hepatic damage in micePathogenesis of alcoholic liver disease: Role of oxidative metabolismPatterns and Correlates of Substance Use among American Indians in Washington State“Native Americans, Neurofeedback, and Substance Abuse Theory”. Three Year Outcome of Alpha/theta Neurofeedback Training in the Treatment of Problem Drinking among Dine' (Navajo) PeopleAlcoholism prevention among Native-American youthNative American Drinking: A Neglected Subject of Study and ResearchNative American crime and criminal justice require criminologists' attentionSubstance use and abuse among Native AmericansElimination of Ethanol in HumansIndividual Differences in Blood and Breath Acetaldehyde Levels and Urinary Excretion of Catecholamines After Alcohol IntakeBiologic Concomitants of AlcoholismBiochemical and Pathological Derangements of the Gastrointestinal Tract following Acute and Chronic Ingestion of EthanolPart four: Women and alcohol in an Indian settlementEthanol Metabolism in Male American Indians and WhitesMetabolic Responses of Chinese, Japanese and Europeans to AlcoholAcute Ethanol Poisoning: A Two-Year Study of Deaths in North CarolinaPHARMACOGENETICS OF ALCOHOLISMPHYSIOLOGIC RESPONSES TO ETHANOL AMONG THE TARAHUMARA INDIANSAnthropological Perspectives on the Social Biology of Alcohol: An Introduction to the LiteratureAlcohol Metabolism in American Indians and Whites3 Alcohol DehydrogenasesAlcoholism and MalnutritionPobough Lang in Senegal 1 February 1972Volume 76, Issue 2Page: 326-327KeywordsAlcoholismAlcoholsBlindnessCirrhosisEthanolGeneticsJewish peopleNative American people Issue Published: 1 February 1972 PDF DownloadLoading ...