Reactive Perforating Collagenosis Associated with Diabetes Mellitus

Abstract

Reactive perforating collagenosis (RPC) is a skin disorder characterized by extrusion of collagen fibers through the epidermis. This rare form of cutaneous perforating disease, first described by Mehregan et al. in 1967,1 usually begins in infancy or childhood and appears clinically as recurrent umbilicated papules that resolve spontaneously in six to eight weeks.2 In some cases the disease is thought to be hereditary.3 , 4 Fewer than 40 cases of RPC have been reported in all the medical literature, and only one or possibly two cases have been associated with chronic renal disease.5 No relation has been established between RPC and diabetes . . .