Concepedia

New 5-HT1A receptor agonists possessing 1,4-Benzoxazepine scaffold exhibit highly potent anti-ischemic effects

Katsuhide Kamei, Noriko Maeda, Ryoko Ogino, Makoto Koyama, Mika Nakajima, Toshio Tatsuoka, Tomochika Ohno, Teruyoshi Inoue

Bioorganic & Medicinal Chemistry Letters · 2001 · 57 citations · 13 references

Open access

Concepts

MedicineMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryNeuropharmacologyHit-to-lead OptimizationLigand BindingReceptor PharmacologySerotonergic Pharmacology5-Hydroxytryptamine 1A Receptor Agonists5-Hydroxytryptamine Receptor PharmacologyLead ScaffoldsSerotonergic Drug Discovery

References

13

Experimental studies of ischemic brain edema

Jin-ichi Koizumi, Yoji Yoshida, Teiji Nakazawa et al. · Nosotchu · 1986 · 981 citations · Full text

Medicine, Neurology, Neuroscience +10

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

J Koizumi · Medical Entomology and Zoology · 1986 · 762 citations

Medicine, Neurology, Neuroscience +15

5-Hydroxytryptamine receptors

Emilie Zifa, G. Fillion · Trends in Pharmacological Sciences · 2001 · 682 citations

Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

Christer Köhler, Håkan Hall, Sven Ove Ögren et al. · Biochemical Pharmacology · 1985 · 506 citations

Medicine, Neuroscience, Pharmacology +12

Pharmacological Differentiation and Characterization of 5‐HT<sub>1A</sub>, 5‐HT<sub>1B</sub>, and 5‐HT<sub>1C</sub>Binding Sites in Rat Frontal Cortex

Stephen J. Peroutka · Journal of Neurochemistry · 1986 · 344 citations

Medicine, Medicinal Chemistry, Pharmacology +16