Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats

Chronic catheterization of the spinal subarachnoid space

Tony L. Yaksh, Thomas A. Rudy · Physiology & Behavior · 1976 · 2.2K citations

Spinal Cord Injury, Spinal Disorder, Surgery +4

Adrenomedullin: A Novel Hypotensive Peptide Isolated from Human Pheochromocytoma

Kenichiro Kitamura, Kenji Kangawa, Masashi Kawamoto et al. · Biochemical and Biophysical Research Communications · 1993 · 2.2K citations

Human Pheochromocytoma, Adrenal Gland, Biochemistry +6

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

J Mao, D.J. Mayer · Journal of Neuroscience · 1994 · 453 citations · Full text

Morphine Tolerance, Thermal Hyperalgesia, Pain Medicine +17

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

Diogo Santos M. da Costa, Flávia Carla Meotti, Edinéia Lemos de Andrade et al. · Pain · 2009 · 217 citations

Trpa1 Present, Acute Pain, Pain Medicine +20

Autocrine/Paracrine Role of Inflammation-Mediated Calcitonin Gene-Related Peptide and Adrenomedullin Expression in Human Adipose Tissue

Philippe Linscheid, Dalma Seboek, Henryk Zulewski et al. · Endocrinology · 2005 · 194 citations · Full text