Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process

Autoxidation versus Covalent Binding of Quinones as the Mechanism of Toxicity of Dopamine, 6-Hydroxydopamine, and Related Compounds toward C1300 Neuroblastoma Cells in Vitro

Doyle G. Graham, S M Tiffany, William R. Bell et al. · Molecular Pharmacology · 1978 · 955 citations

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

H. Sauer, Wolfgang H. Oertel · Neuroscience · 1994 · 790 citations

Nigrostriatal Dopamine Neurons, Progressive Degeneration, Neurophysiology +11

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.

Teresa G. Hastings, David A. Lewis, Michael J. Zigmond · Proceedings of the National Academy of Sciences · 1996 · 545 citations · Full text

Neurotoxicology, Neurotoxic Effects, Psychopharmacology +16

Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6-hydroxydopamine

S. Przedbroski, M. Leviver, Hong Jiang et al. · Neuroscience · 1995 · 444 citations · Full text

6-Hydroxydopamine Lesion of the Rat Substantia Nigra: Time Course and Morphology of Cell Death

Beom S. Jeon, Vernice Jackson‐Lewis, Robert E. Burke · Neurodegeneration · 1995 · 277 citations · Full text

Cell Death, Social Sciences, Rat Substantia Nigra +17