Differential Effects of High-fat and High-carbohydrate Content Isoenergetic Meals on Plasma Active Ghrelin Concentrations in Lean and Obese Women

Abstract

A fat-rich meal does not suppress plasma active ghrelin levels in either lean or obese women. Moreover, in obese, unlike lean women, a high carbohydrate meal also fails to suppress plasma ghrelin levels, which are already quite low. This suggests that ghrelin-induced satiety mechanisms may be compromised in these subjects.