Nitrogenous metabolites from the deep water sponge <i>Hexadella</i> sp.

Abstract

The secondary metabolites of the sponge Hexadella sp., collected by SCUBA (−40 m) and manned submersible (−100 to −200 m) in Jervis Inlet, British Columbia, have been examined. The submersible-collected material contained only the previously reported compound topsentin B2 (1). Sponge material collected in shallower water via SCUBA contained hexadellins A (2) and B (3), two new dibromotyrosine derived metabolites. The structures of 2 and 3 were determined by spectroscopic analysis of the diacetyl derivatives 6 and 7. Keywords: sponge, metabolite, Hexadella, nitrogenous.