A peptide inhibitor of angiotensin I converting enzyme in the tryptic hydrolysate of casein.

Abstract

Angiotensin converting enzyme (ACE) is a peptidyldipeptide hydrolase (EC 3.4.15. 1) which cleaves dipeptides from the free COOH-terminal of peptides. The enzyme hydrolyzes both angiotensin I and bradykinin, generating the potent vasoconstrictor angiotensin II from angiotensin I, and vasoinactive peptides from the vasodilator bradykinin. Inhibitors of ACEwere first obtained from the