Copper‐Catalyzed Efficient Multicomponent Reaction: Synthesis of Benzoxazoline‐Amidine Derivatives

Abstract

Abstract We have developed an efficient copper‐catalyzed method for the synthesis of the benzoxazoline‐amidine derivatives. The protocol uses inexpensive copper(I) iodide as the catalyst, and furnished the expected product in good to excellent yields by a three‐component reaction of sulfonyl azides, terminal alkynes and Schiffs’ bases in terahydrofuran (THF) at room temperature for 8 h in the presence of triethylamine. This novel synthetic protocol is selective, efficient and general. A plausible mechanism for this process is proposed.