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Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica
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1989
Year
Antimalarial AgentBioorganic ChemistryAntiparasitic AgentMalariaMedicinal FungiPlant PathologyChemical BiologyMedicinal ChemistryNoe DifferencePhytopharmacologyAzadirachta IndicaParasitologyColoc ExperimentsPhytoalexinAllergyBiochemistryBioassay-guided IsolationPharmacologyNatural SciencesHerbal MedicinePhytochemistryMedicineDrug Discovery
The isolation and structure elucidation of gedunin [1], the antimalarial agent of Azadirachta indica, are reported. Its 1H- and 13C-nmr spectra were assigned by using one- and two-dimensional nmr spectroscopy, especially homonuclear and heteronuclear COSY, nOe difference, and COLOC experiments.