Myocardial Protection by Na⁺-H⁺Exchange Inhibition in Ischemic, Reperfused Porcine Hearts

Abstract

This study clearly demonstrates that Na(+)-H+ exchange is an important mechanism for cell death in myocardial ischemia and reperfusion in intact pigs; thus, inhibition of this exchange system may prove a promising new strategy in the clinical treatment of myocardial ischemia and reperfusion.