Delayed Cutaneous Hypersensitivity to Leukocytes in Disseminated Lupus Erythematosus

Abstract

RECENT work from this laboratory indicates that patients who have rejected skin homografts manifest a "delayed" type of hypersensitivity to homologous leukocytes. This is evidenced by typical erythema and induration at the local site of an intradermal injection of leukocytes obtained from the peripheral blood of donors.1 Since both the rejection of a skin homograft and the manifestations of disseminated lupus erythematosus may be mediated through "antitissue antibodies" this work was extended to patients with the disease.A patient receiving intramuscular leukocyte injections as therapy for disseminated lupus2 was found to have a strongly positive test to intradermally administered leukocytes. . . .