Characterization of Somatostatin Receptor Subtype-Specific Regulation of Insulin and Glucagon Secretion: An <i>in Vitro</i> Study on Isolated Human Pancreatic Islets

Abstract

Our study demonstrates that SSTR2-agonist is the most potent inhibitor of insulin and glucagon secretion from isolated human pancreatic islets. Furthermore, we identify SSTR1- and SSTR5-selective agonists as additional inhibitors of insulin and glucagon secretion from human pancreas.