A novel mitochondrial mutation, 1556C→T, in a Japanese patient with streptomycin-induced tinnitus

Abstract

The 1556C --> T mutation may be a genetic risk factor for aminoglycoside-induced hearing impairment. Our result also suggests that patients with the 1556C --> T mutation exist among those expected to have the 1555A --> G mutation as a result of PCR-RFLP analysis.