Publication | Closed Access
Olefin Metathesis: Remote Substituents Governing the Stereoselectivity of 11-Membered-Ring Formation
29
Citations
5
References
2003
Year
EngineeringAlkene MetathesisBiochemistryNatural SciencesRemote SubstituentsMolecular BiologyOrganic ChemistryRcm/rom/rcm TransformationStereoselective SynthesisChemistryHeterocycle ChemistryBiomolecular Engineering
[reaction: see text] Stereospecific RCM reaction of 7 (R1 = Me) results in the formation of (Z)-11-membered macrocycle 9c. Cascade RCM/ROM/RCM transformation of 7 (R1 = H) affords the thermodynamically more stable spirocycle product 12.
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