Decrease of Human Serum Fucosyltransferase as an Indicator of Successful Tumor Therapy

Abstract

Surgical removal of colon carcinomas leads to a decrease in the rate of incorporation of [ 14 C]fucose into its endogenous acceptor in human serum; normal incorporation rates are attained within 14 days. A similar time course has been determined for α 2 - and α 3 -fucosyltransferase when either desialo- or desialodegalactofetuin are employed as exogenous acceptors. A correlation has also been seen between transferase activity and the therapeutic response of patients with breast cancer. These results indicate that the determination of fucosyltransferase activity can facilitate the diagnosis of neoplasia, and the success of surgery, chemotherapy, or radiation.