The UV Erythema Test as a Model to Investigate the Anti-Inflammatory Potency of Topical Preparations – Reevaluation and Optimization of the Method

Abstract

The UV erythema test should be performed on the back with at least 40 subjects using the 1.5-fold MED. It may be useful to include a potent corticosteroid, such as prednicarbate or betamethasone valerate, in addition to hydrocortisone. The UV erythema test seems to be suitable only for substances with corticosteroid-like effects, since in this test model the calcineurin inhibitor pimecrolimus was not effective.