Cefotaxime concentrations in otitis media effusions

Abstract

Ten children with acute otitis media were treated with cefotaxime given by intramuscular or intravenous injection in doses of 50 or 100 mg/kg/day. Middle ear effusion was obtained by paracentesis and 1 h after dosing contained mean concentrations of 2 mg/l for those give 50 mg/kg/day and 17.5 mg/l for those given 100 mg/kg/day.