Chiral Discrimination of 1-Phenylethylamine by Diastereomeric Salt Formation with Bile Acids. Crystal Structures of Cholic Acid Salts with (<i>R</i>)- and (<i>S</i>)-1-Phenylethylamine

Abstract

Abstract Chiral discrimination of 1-phenylethylamine (1) by diastereomeric salt formation with bile acids is described. X-ray crystallographic studies of the salts between cholic acid (2a) and (R)-, (S)-, and (RS)-1 reveal that more densely packed (S)-1+2a salt crystallizes preferentially by treatment of 2a from racemic 1.