Unilateral "Page kidney" hypertension in man. Studies of the renin-angiotensin-aldosterone system before and after nephrectomy

Abstract

Hypertension developed in a 17-year-old boy one year after a flank injury. Intravenous pyelography showed a slightly smaller kidney on the injured side. Renal arteriography demonstrated unilateral decreased vascular filling. Renal vein renin ratios suggested an ischemic kidney, as did splitfunction studies. Nephrectomy cured the hypertension. Detailed studies before and after nephrectomy suggested that hyperactivity of the renin-angiotensin-aldosterone system may participate in the pathophysiology of this unusual cause of hypertension in man. (<i>JAMA</i>231:42-45, 1975)