Long-continued Inhibition of Gastric Secretion by Poldine Methosulphate in Patients with Peptic Ulcer

Abstract

Antacids are widely used to control pain and promote healing in patients with peptic ulcer. Although antacids, provided they are taken often enough and in large quantities (Clark and Hunt, 1958), are unquestionably effective in maintaining a lowered acidity in the gastric contents during the day, they have no influence on the acidity of the gastric contents during sleep. Instead of neutralizing the acid after it is secreted, it would seem better to try to inhibit the secretion of acid continuously even when the patient is in remission. This paper is concerned with treatment of patients with peptic ulcer along these lines, using an anticholinergic substance, poldine methosulphate (" nacton "), which reduces by about one-half the gastric secretion of acid without producing noticeable side-effects.