In vivo assessment of neurodegeneration in niemann‐pick type C mice by quantitative T2 mapping and diffusion tensor imaging

Abstract

The findings of this study suggest that quantitative MRI measurements may be suitable in vivo biomarkers of disease status for future studies of NPC disease models. The changes in white matter measurements between timepoints in both control and NPC disease groups suggest that white matter structures continue to change and develop over time in the NPC model and can be tracked with MRI techniques.