Concepedia

Fine-Mapping Loss of Gene Architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP Genes in Head and Neck Squamous Cell Carcinoma

Maria J. Worsham, Kang Mei Chen, Nivedita Tiwari, Gerard Pals, Jan P. Schouten, Seema Sethi, Michael S. Benninger

Archives of Otolaryngology - Head and Neck Surgery · 2006 · 69 citations · 36 references

DOI

Abstract

We identified exon 1alpha (p16(INK4a)) as the smallest region of loss in the CDKN2A(ARF, INK4a) gene. The frequency and precise loss of CDKN2B(INK4b), CDKN2A(ARF, INK4a), and MTAP in the prognosis of 9p21-deleted HNSCC may provide impetus for use of these targets as therapeutic biomarkers in head and neck cancer.

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